Whether you're a visitor seeking to expand your Czech experience beyond the capital or a local in need of a peaceful escape, Prague offers access to some of the most refined weekend getaways in Central Europe. From spa towns and castles to vineyard estates and countryside retreats, each destination is within 2–3 hours of the city—ideal for a short luxury break.

This guide highlights top-tier weekend destinations, including where to stay, what to do, and how to get there.

Karlovy Vary – Spa Elegance & Old-World Glamour

Travel Time: 2 hours by car or train

Why Go: Historic hot springs, grand colonnades, and spa heritage.

Top Stay:

  • Grandhotel Pupp – Legendary 5-star hotel featured in Casino Royale, with a full wellness center and riverside charm.

What to Do:

  • Soak in thermal springs or book a full balneotherapy program

  • Attend a concert or film screening at the Pupp cultural hall

  • Stroll the Mill and Market colonnades, sip mineral water from the springs

  • Try the herbal liqueur Becherovka at its museum

Mariánské Lázně – Secluded Wellness & Forest Views

Travel Time: 2.5 hours by car

Why Go: Elegant spa town with pristine air and peaceful walking trails.

Top Stay:

What to Do:

  • Enjoy healing mineral baths and CO₂ therapy

  • Explore nearby forests and singing fountain promenades

  • Play a round at the Royal Golf Club Mariánské Lázně

Mikulov – Wine Country in South Moravia

Travel Time: 2.5–3 hours by car

Why Go: Rolling vineyards, baroque castles, and top-tier Moravian wines.

Top Stay:

  • Hotel Volarik Mikulov – A modern luxury hotel with a rooftop infinity pool, located in the heart of wine country.

What to Do:

  • Visit Mikulov Castle and climb Holy Hill for views

  • Book a private wine tasting at a family-owned cellar

  • Cycle or drive through the Pálava hills and UNESCO Lednice-Valtice complex

Chateau Herálec – Castle Luxury in the Countryside

Travel Time: 1.5 hours by car

Why Go: A true castle stay with a world-class spa in the tranquil Vysočina Highlands.

Top Stay:

  • Chateau Herálec Boutique Hotel & Spa – 13th-century Renaissance castle turned 5-star boutique hotel, featuring an indoor pool, L’Occitane spa, and gourmet cuisine.

What to Do:

  • Indulge in spa treatments and gourmet menus

  • Walk or bike in the surrounding countryside

  • Take a private helicopter tour (available via the hotel)

Český Krumlov – Romantic Riverside Fairytale

Travel Time: 2.5–3 hours by car

Why Go: UNESCO-listed town with a storybook medieval center.

Top Stay:

  • Hotel Růže – A former Jesuit college turned historic hotel, located near the castle.

What to Do:

  • Explore Český Krumlov Castle and its gardens

  • Paddle the Vltava River or join a photography walk

  • Dine riverside at one of the town’s Michelin-recommended restaurants

Liblice – A Baroque Palace Experience

Travel Time: 45 minutes from Prague

Why Go: Historic palace getaway ideal for spa lovers who want to stay closer to the city.

Top Stay:

  • Chateau Liblice Hotel & Spa – A Baroque chateau with a wellness zone, wine cellar, and formal gardens.

What to Do:

  • Enjoy steam baths and body rituals in the palace spa

  • Take a carriage ride through the grounds

  • Dine in the palace restaurant with garden views

Planning Tips for Weekend Luxury Trips from Prague

  • Book spa treatments in advance, especially in Karlovy Vary or Mariánské Lázně.

  • For countryside properties like Herálec or Mikulov, driving is recommended for flexibility.

  • If staying at a chateau or vineyard hotel, check for seasonal packages (e.g. wine harvest weekends, yoga retreats).

  • Don’t overlook Monday check-outs — many guests leave Sunday afternoon, but Sunday night is often quieter and more affordable.

Compare Luxury Hotels from Prague and Beyond

Whether you’re looking for spa serenity, vineyard romance, or historic immersion, these handpicked weekend getaways from Prague promise luxury with a local soul.

Explore real-time prices, reviews, and best booking options on ResortPoppy.com.